Succinylacetone is a chemical compound that is formed by the oxidation of glycine and is a precursor of methylglyoxal. \nIt is a pathognomonic compound found in the urine of patients with tyrosinemia type 1, which is due to congenital deficiency of an enzyme, fumarylacetoacetate hydrolase. This enzyme is involved in the catabolism of tyrosine, and if deficient, leads to accumulation of fumarylacetoacetate which is subsequently converted to succinylacetone which can be detected in the urine by GCMS. Succinylacetone also inhibits ALA dehydratase which increases ALA and precipitates acute neuropathic symptoms, similar to porphyria.
"}{"slip": { "id": 10, "advice": "Never pay full price for a sofa at DFS."}}
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{"type":"standard","title":"Quercus peninsularis","displaytitle":"Quercus peninsularis","namespace":{"id":0,"text":""},"wikibase_item":"Q5502730","titles":{"canonical":"Quercus_peninsularis","normalized":"Quercus peninsularis","display":"Quercus peninsularis"},"pageid":12911677,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/0/0a/Quercus_peninsularis_42378286.jpg/330px-Quercus_peninsularis_42378286.jpg","width":320,"height":427},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/0/0a/Quercus_peninsularis_42378286.jpg","width":1536,"height":2048},"lang":"en","dir":"ltr","revision":"1281427306","tid":"46253dd0-056a-11f0-b14e-5b3e7fd0ff88","timestamp":"2025-03-20T09:04:05Z","description":"Species of oak tree","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Quercus_peninsularis","revisions":"https://en.wikipedia.org/wiki/Quercus_peninsularis?action=history","edit":"https://en.wikipedia.org/wiki/Quercus_peninsularis?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Quercus_peninsularis"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Quercus_peninsularis","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Quercus_peninsularis","edit":"https://en.m.wikipedia.org/wiki/Quercus_peninsularis?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Quercus_peninsularis"}},"extract":"Quercus peninsularis, common name peninsular oak, is a species of oak endemic to Baja California, Mexico. It is a shrub or small tree to 10 m, occurring in mountain valleys and canyons up to 3000 m. It is placed in section Lobatae. Leaves are 5–8 cm, flat, leathery and hairy, with pointed tips and 2–5 pairs of teeth. Flowers occur in 3 cm catkins. Fruits are 1.5 cm acorns, stemless, ovoid, with hairy cupules, maturing in a year. Mature bark is reddish; young twigs are thin and hairy.","extract_html":"
Quercus peninsularis, common name peninsular oak, is a species of oak endemic to Baja California, Mexico. It is a shrub or small tree to 10 m, occurring in mountain valleys and canyons up to 3000 m. It is placed in section Lobatae. Leaves are 5–8 cm, flat, leathery and hairy, with pointed tips and 2–5 pairs of teeth. Flowers occur in 3 cm catkins. Fruits are 1.5 cm acorns, stemless, ovoid, with hairy cupules, maturing in a year. Mature bark is reddish; young twigs are thin and hairy.
"}